Wednesday, Nov. 28 (HealthDay News) - A new antibody , lab created that mimics the action of a natural molecule causes weight loss in monkeys weight loss drug monkey, researchers report weight loss monkey.
The engineered antibody also appears to improve insulin sensitivity weight loss monkey, which could fight against type 2 diabetes , weight loss for monkey and lower levels of triglycerides, weight loss drug monkey a blood fat that contributes to hardening of the arteries .
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"The results that we describe in animal models are deep and very encouraging," said lead study author Yang Li, Chief Scientific Officer of Amgen , Inc. in Thousand Oaks , Calif . " Although we are very pleased with these results weight loss for monkey, we are still evaluating the results . "
Li said it is important to remember that these results were only monkeys and preclinical environment . weight loss drug monkeyIt is still unclear how this treatment could act in humans weight loss for monkey.
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The study was funded by Amgen, the developer of this new treatment weight loss monkey. The results appear in the issue of Science Translational Medicine on November 28 .
Obesity and its frequent companion, type 2 diabetes are growing problems in the United States that threatens to overwhelm the health care system if they continue to increase, according to the U.S. weight loss drug monkey Centers for Disease Control and Prevention weight loss monkey.
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Obesity treatments are generally not effective in the long term , while drugs are available for type 2 diabetes weight loss for monkey, many people with the disease are not able to achieve the levels of blood sugar enough low to avoid complications weight loss monkey, weight loss drug monkey according to the American Diabetes Association.
The current study began by looking at a molecule called fibroblast growth factor 21 ( FGF21 ) . This molecule has gained a lot of interest weight loss drug monkey in research, since lately it seems to have many positive effects on obesity and type 2 diabetes , weight loss for monkey according to the study .
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In the body, FGF21 is induced during fasting or starvation. Scientists are still trying to understand how FGF21 causes beneficial changes , but they suspect it weight loss monkey may enable less frequent but more metabolically active brown fat weight loss drug monkey.
FGF21 in the development of a treatment is a challenge, said Li, because the molecule is not stable in the blood. This means that any treatment developed from the native protein may require frequent injections , he said .
In the current research, Li and his colleagues took a different approach. Instead of looking FGF21 , researchers have tried to find other more stable forms activate the same pathways activated by FGF21 .
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Researchers have developed an alternative in the laboratory - an antibody called mimAb1 weight loss monkey. They tested the new antibody in 10 obese monkeys and compared them with 10 obese monkeys in the control group.
Weight loss monkey The monkeys in the treatment group received two injections - one of the first week and again in the third week weight loss monkey. Five to six weeks after the first injection, the monkeys lost 10 percent of their body weight. Reductions in body weight were maintained at least nine weeks after the second injection weight loss drug monkey.
In addition, weight loss seems to occur even without significant reduction in calories , said Li .
In addition to weight loss and improve insulin sensitivity , abdominal circumference animals and body mass index (BMI ) was reduced weight loss monkey. The BMI is a measure of the size based on the body weight and fat weight loss drug monkey.
" When we tested mimAb1 in the animal model , we have seen many positive changesweight loss monkey. Results are very encouraging ," said Li . He added that they had no significant side effects , including blood sugar .
Dr. Spyros Mezitis , an endocrinologist at Lenox Hill Hospital in New York, said the study was well done, but it is very preliminary .
" There is a promise here weight loss monkey. This route has beneficial effects when lit, and needs further study ," said Mezitis. "You have to make sure it works the same way in humans, and it is safe. It could take years to emerge . "
He said it is possible that , despite this particular treatment can not be the solution for obesity or human diabetes , which can provide more clues about the mechanisms underlying these conditions.
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